Imaging of Gene Expression in Live Pancreatic Islet Cell Lines Using Dual-Isotope SPECT
نویسندگان
چکیده
منابع مشابه
Imaging of gene expression in live pancreatic islet cell lines using dual-isotope SPECT.
UNLABELLED We are combining nuclear medicine with molecular biology to establish a sensitive, quantitative, and tomographic method with which to detect gene expression in pancreatic islet cells in vivo. Dual-isotope SPECT can be used to image multiple molecular events simultaneously, and coregistration of SPECT and CT images enables visualization of reporter gene expression in the correct anato...
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Objective(s): Use of a positron emission tomography (PET)/single-photonemission computed tomography (SPECT) system facilitates the simultaneousacquisition of images with fluorine-18 fluorodeoxyglucose (18F-FDG) andtechnetium (99mTc)-tetrofosmin. However, 18F has a short half-life, and 511keV Compton-scattered photons are detected in the 99mTc energy window.Therefore, in this study, we aimed to ...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2007
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.107.043430